Cholera and caffeine are somewhat similar. Right? Both the cholera toxin and caffeine potentiate the cAMP response, ableit in different ways. Caffeine acts as an antagonist to phosphodiesterase, an enzyme that breaks down cAMP, thus increasing the time cAMP remains active in the cell. The cholera toxin, on the other hand, binds the G alpha protein and causes increased activation of adenylate cyclase, the enzyme that produces cAMP.

Now. What are the effects of cholera? Diarrhea. And coffee? The shits.

So cholera and caffeine are somewhat similar.